1. Reading makes a full amn, meditation a profound man, discourse a clear man. 

2. Her sense of disappointment was profound.

3. I heard of his death with profound/deep/great regret.

4. The report has profound implications for schools.

5. Her speech made a profound impact on everyone.

6. Life is a profound book.

7. He had a profound influence on modern poets.

8. The news came as a profound shock.

9. Despite the decay the mosque somehow retained a profound grandeur.

10. My father's death had a profound effect on us all.

11. Tolstoy's experiences of war had a profound effect on his work.

12. I give you my profound thanks for saving my life.

13. Life is a profound book.Other's notes cannot replace your own understanding.May you find and create something new in it.

14. We have just learned with profound sorrow of the passing away of...

15. It's a quite profound story, with powerful religious overtones.

16. She has a profound hatred of fascism.

17. We had a profound lesson in ideological education yesterday.

18. She spoke of them with profound reverence.

19. A profound silence prevailed over all.

20. Jenner is a profound thinker.

21. He has a profound knowledge of mathematics.

22. Joe had a profound distaste for violence.

23. Her rape had a profound psychological effect on her.

24. Her work touches something profound in the human psyche.

25. I feel a profound antipathy to using any weapon.

26. The indirect effects of climate change may be profound.

27. His mother's death when he was aged six had a very profound effect on him.

28. For college students to do a part-time job will exert a profound influence on their personality and life.

29. All at once he fell into a state of profound melancholy.

30. Her simple style is deceptive: what she has to say is very profound.